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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T17879 | E3 ligase Ligand 8 | Others , Ligand for E3 Ligase | |
E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. The E3 ligase Ligand 8 can be linked to protein ligands through linkers to form PROTACs, which are inducers of ubiquitination-mediated degradation of cancer-promoti... | |||
T40503 | Thalidomide-5-methyl | Ligand for E3 Ligase | |
Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand. Thalidomide-5-methyl is used in the recruitment of CRBN protein. | |||
T14893 | CC-885 | Others , Ligand for E3 Ligase | |
CC-885 is a modulator of cereblon (CRBN). It has potent anti-tumour activity. | |||
T18831 | Thalidomide-propargyl | Others , Ligand for E3 Ligase | |
Thalidomide-propargyl, a Thalidomide-derived Cereblon ligand, facilitates the recruitment of Cereblon. It can be attached to the protein ligand via a linker, producing IMiD-containing PROTACs. | |||
T18066 | Lenalidomide-OH | Ligand for E3 Ligase | |
Lenalidomide-OH is a ligand of cereblon (CRBN), serving as an analog to Lenalidomide for E3 ubiquitin ligase. It is utilized in the recruitment of CRBN protein. Additionally, Lenalidomide-OH can be conjugated to a protei... | |||
T5334 | VL285 | Others , Ligand for E3 Ligase | |
VL285 is a potent VHL ligand, degrading HaloTag7 fusion proteins. | |||
T9809 | E3 ligase Ligand 23 | Ligand for E3 Ligase | |
E3 ligase Ligand 23 is a cereblon binder and degrades Ikaros or Aiolos through ubiquitin proteasome. | |||
TQ0121 | VH-298 | Others , HIF , Ligand for E3 Ligase | |
VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein-protein interaction downstream of HIF-α hydroxylation by P... | |||
T10359 | AR antagonist 1 | Androgen Receptor , Ligand for E3 Ligase , Ligands for Target Protein for PROTAC | |
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266. | |||
T18064 | Lenalidomide-Br | Ligand for E3 Ligase | |
Lenalidomide-Br (Compound 41) is a derivative of Lenalidomide, which serves as a ligand for cereblon (CRBN) - an E3 ubiquitin ligase involved in protein recruitment. This compound, Lenalidomide-Br, can be conjugated to a... | |||
T7763 | Thalidomide-4-OH | Cereblon ligand 2,E3 ligase Ligand 2 | Ligand for E3 Ligase |
Thalidomide-4-OH (E3 ligase Ligand 2) (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used to recruit of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) is a linker to form PROTACs | |||
T0213 | Thalidomide | Thalomid,Sedoval | Apoptosis , TNF , Autophagy , Ligand for E3 Ligase , Molecular Glues |
Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties. | |||
T7752 | (S,R,S)-AHPC-Me | VHL ligand 2,E3 ligase Ligand 1A | Ligand for E3 Ligase |
(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me can be used to synthesize ARV-771. ARV-771 is a... | |||
T8824 | CRBN modulator-1 | WUN29654 | Others , Ligand for E3 Ligase |
CRBN modulator-1 (WUN29654) is a Thalidomide analog and CRBN modulator,has an IC50 of 3.5 μM and a Ki of 0.98 μM. | |||
T60024 | CFT7455 | Cemsidomide | Ligand for E3 Ligase |
CFT7455 (Cemsidomide) is an anti-cancer agent showing high affinity to the cereblon E3 ligase with a Kd of 0.9 nM. CFT7455 is an orally active degrader of zinc finger transcription factors Ikaros (IKZF1), and Aiolos (IKZ... | |||
T40019 | Thalidomide-5-NH2-CH2-COOH | Others | |
Thalidomide-5-NH2-CH2-COOH (compound 114) is a selective inhibitor of the protomyosin receptor kinase. It is a ligand for E3 ligase and has potential for studying one or more diseases. | |||
T22922 | Lenalidomide hemihydrate | TNF , Ligand for E3 Ligase , Molecular Glues | |
Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage binding protein-1 (DDB1) complexes. | |||
T5821 | BC-1215 | Others , Ligand for E3 Ligase | |
BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release). | |||
T7753 | Thalidomide-O-COOH | Cereblon ligand 3,E3 ligase Ligand 3,TCE35031 | Others , Ligand for E3 Ligase |
Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a linker to form PROTACs. | |||
T2384 | Pomalidomide | CC-4047 | Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues |
Pomalidomide (CC-4047) inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an anti-angiogenic agent and an immunomodulator. | |||
T7755 | Thalidomide 4-fluoride | E3 ligase Ligand 4 | IRAK , Ligand for E3 Ligase |
Thalidomide 4-fluoride (E3 ligase Ligand 4) (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand. Thalidomide 4-fluoride can be used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) ... | |||
T17877 | VH032-cyclopropane-F | VHL ligand 3,E3 ligase Ligand 19,Phenolic VH101 | Others , Ligand for E3 Ligase |
VH032-cyclopropane-F (Phenolic VH101) is a VH032-based VHL ligand. VH032-cyclopropane-F can be connected to the ligand for protein by a linker to form PROTACs. PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4. | |||
T13671 | (S,R,S)-AHPC-Me hydrochloride | VHL ligand 2 hydrochloride,E3 ligase Ligand 1 | Others , Ligand for E3 Ligase |
(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degrader. This compound selectively degrades BET protein in cell... | |||
T1642 | Lenalidomide | CC-5013 | Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues |
Lenalidomide (CC-5013) is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines. | |||
T10765 | Eragidomide | CC-90009,Cereblon modulator 1 | Apoptosis , Ligand for E3 Ligase , Molecular Glues |
Eragidomide (CC-90009; Cereblon modulator 1) is a cereblon (CRBN) E3 ligase modulator. Eragidomide specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex. | |||
T9291 | Thalidomide-5-OH | 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione | Others , Ligand for E3 Ligase |
Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) is the Thalidomide-based cereblon ligand that used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a link... | |||
T7791 | Iberdomide | CC-220 | Apoptosis , Ligand for E3 Ligase |
Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay). | |||
T9381 | Thalidomide 5-fluoride | H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro- | Ligand for E3 Ligase |
Thalidomide 5-fluoride (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-) is a thalidomide-based Cereblon ligand that binds to the IRAK4 protein ligand via a linker to form PROTACIRAK4 degrader-1. | |||
T13877 | (S,S,S)-AHPC hydrochloride | (S,S,S)-VH032-NH2 hydrochloride | Ligand for E3 Ligase |
(S,S,S)-AHPC hydrochloride ((S,S,S)-VH032-NH2 hydrochloride) is a VHL amino building block, is a ligand used as a negative control for (S,R,S)-AHPC. It is the VH032-based VHL ligand used in the recruitment of the VHL pro... | |||
T8412 | (S,R,S)-AHPC | VH032-NH2,MDK7526,VHL ligand 1 | Others , Ligand for E3 Ligase |
(S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC is potential useful for the targeted degradation of the androgen receptor. | |||
T17927 | (S,R,S)-AHPC TFA | VH032-NH2 TFA,VHL ligand 1 TFA | Others , Ligand for E3 Ligase |
(S,R,S)-AHPC TFA (VHL ligand 1 TFA) (VH032-NH2 TFA) is a VH032-based ligand designed for von Hippel-Lindau (VHL) protein recruitment. This compound can be linked to protein ligands (e.g., BCR-ABL1) using a linker to crea... | |||
T4207 | (S,R,S)-AHPC hydrochloride | VHL Ligand 1 hydrochloride,ULM-1,Protein degrader 1 hydrochloride | Others , Ligand for E3 Ligase |
(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs). | |||
T40016 | Thalidomide-NH-CH2-COOH | 2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetic acid,(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine | Ligand for E3 Ligase |
Thalidomide-NH-CH2-COOH ((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine) is a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker. | |||
T17870 | CIAP1 ligand 1 | E3 ligase Ligand 12 | Others |
cIAP1 ligand 1 (E3 ligase Ligand 12) is an apoptotic protein ligand based on the LCL161 derivative that recruits IAP ubiquitin ligases to degrade target proteins, and can be used to couple with androgen receptor ligands ... | |||
T15125 | Diethylene Glycol Monobenzyl Ether | Others | |
Diethylene Glycol Monobenzyl Ether is a PEG-based linker, specifically designed for the synthesis of PROTACs[1]. It serves as a versatile chemical compound, enabling the formation of PROTAC molecules by connecting target... | |||
T77965 | DCAF1 binder 1 | ||
DCAF1 Binder 1 selectively targets the CRL4 DCAF1 E3 ligase complex as a ligand, playing a role in targeted protein degradation (TPD) [1]. | |||
T17345 | 7-Octynoic acid | Others | |
7-Octynoic acid (compound 42) serves as a PROTAC linker for synthesizing various PROTACs, which are composed of two distinct ligands joined by this linker. One ligand interacts with an E3 ubiquitin ligase, while the othe... | |||
T18542 | Phthalimide-PEG3-C2-OTs | Others | |
Phthalimide-PEG3-C2-OTs (Compound 5) is a PROTAC linker composed of PEGs. It is utilized in the synthesis of various PROTACs, which involve the connection of two distinct ligands through a linker. One ligand is specific ... | |||
T79250 | PROTAC α-synuclein degrader 5 | PROTACs | |
PROTAC α-synuclein degrader 5 is a highly selective (PROTAC) compound that targets and degrades α-synuclein aggregates, exhibiting an DC50 value of 7.51 μM and achieving a maximum degradation rate (Dmax) of 89%. The comp... | |||
T83953 | Pomalidomide 4'-PEG5-amine | ||
Pomalidomide 4'-PEG5-amine, a cereblon ligand designed for PROTAC research and development, features an integrated E3 ligase ligand and a PEG5 linker ending in an amine for easy conjugation to target protein ligands. It ... | |||
T83954 | VH 032 amide-alkylC7-acid | (S,R,S)-AHPC-amido-C7-acid | |
VH 032 amide-alkylC7-acid is a specialized compound designed for PROTAC research and development, serving as a functionalized von-Hippel-Lindau (VHL) protein ligand. It combines an E3 ligase ligand with an alkylC7 linker... |